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Omeprazole

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What is Omeprazole?

Omeprazole is a proton-pump inhibitor that is prescribed to treat conditions associated with a high level of stomach acid, such as heartburn, acid reflux, and indigestion.

Doctors may also prescribe this medicine to heal and prevent peptic ulcers (painful sores in the stomach), and Zollinger-Ellison syndrome, a rare condition that causes the stomach to produce too much acid. Additionally, Omeprazole can be prescribed together with certain antibiotics to treat stomach infections caused by the Helicobacter pylori bacteria.

Omeprazole is also the active ingredient in the branded medicines Losec and Pyrocalm. While these medicines contain the same active ingredient, they differ in the name, cost, and some added ingredients.

How does Omeprazole work?

Omeprazole belongs to a class of medications called ‘proton pump inhibitors’. The lining of the stomach has cells that contain proton pumps. These are enzymes responsible for releasing acid into the stomach to help digest food. Sometimes, these pumps can produce too much stomach acid which can cause uncomfortable symptoms. Omeprazole binds to these proton pumps and blocks them. This reduces overall stomach acidity.

By lowering stomach acid levels, Omeprazole relieves symptoms of acid reflux, heartburn, and stomach ulcers. It also protects the stomach lining, allowing it to heal.

What are the benefits?

Other than relieving the symptoms of acid reflux, Omeprazole offers many benefits, such as:

  • Long-lasting 24-hour relief with a single daily dose.
  • Protection against stomach ulcers and gastrointestinal bleeding, especially when using nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen.
  • Comes in different strengths for tailored dosing.

How effective is Omeprazole?

Omeprazole has been proven to be very effective in treating symptoms of heartburn in studies.

In a clinical trial involving 355 patients with gastro-oesophageal reflux disease (GORD), the effectiveness of Omeprazole 20 mg and 10 mg doses was compared to a placebo. Participants were divided into three groups, each receiving one of the treatments over a 4-week period.

The results showed that 62% of patients taking Omeprazole 20 mg experienced no heartburn symptoms at day 7, compared to 41% of patients taking Omeprazole 10 mg and 14% of patients taking the placebo.

Bar graph showing the clinical trial results of Omeprazole 20 mg capsules, Omeprazole 10 mg capsules and a placebo

This study showed that a daily dose of Omeprazole 20mg was more effective than both Omeprazole 10mg and placebo in quickly and consistently reducing heartburn and other GORD symptoms.

Who can and cannot use it?

Omeprazole can be used for a variety of conditions however, it may not be suitable for certain groups of people.

Who can use this medicine?

At euroClinix, our doctors are able to prescribe this medication to adults who experience chronic acid reflux.

Who cannot use this medicine?

Do not use Omeprazole if you are allergic to proton pump inhibitors (e.g., omeprazole, lansoprazole, pantoprazole, esomeprazole, esomeprazole), or any of the other ingredients in this medicine.

Similarly to other proton pump inhibitors, Omeprazole should not be used together with the antiretroviral medicines used to treat HIV (e.g., nelfinavir, atazanavir).

You should also tell your doctor if you:

  • have severe liver or kidney problems.
  • have experienced an adverse skin reaction to treatments that reduce stomach acid in the past.
  • are due to have a Chromogranin A test.
  • have a vitamin B12 deficiency or take vitamin B12 supplements.
  • have low magnesium levels.

What Omeprazole dosages are available?

Omeprazole is available in multiple dosages, including 10 mg, 20 mg, and 40 mg strengths. It is also available as tablets, capsules, an oral suspension, and a powder for infusion.

At euroClinix, we currently offer Omeprazole capsules in 10 mg and 20 mg strengths.

How and when should I take Omeprazole?

Always make sure to take this medicine exactly as your doctor has told you. If you are unsure, check with your doctor.

How to take it

To treat gastro-oesophageal reflux disease, the recommended dose is one 20 mg capsule daily for 4 or 8 weeks. Your dosage may vary depending on how severe your symptoms are. 10 mg is intended for less frequent or less severe symptoms.

To take this medicine correctly, follow these instructions:

  • Take one capsule once daily in the morning. The capsules should be swallowed whole with half a glass of water.
  • You can take the capsules with food or on an empty stomach.
  • Do not crush or chew the capsules, as it will reduce the effectiveness of the medication.

If you have trouble swallowing the capsules, you can open the capsule and pour the contents into a glass of still water, acidic fruit juice (e.g., apple, orange, or pineapple), or apple sauce. Make sure to stir the mixture prior to drinking it (it should be taken immediately or within 30 minutes of making the mixture). To make sure you have taken the full dose of the medicine, rinse the glass with a little water and drink it.

For further information, consult the patient information leaflet.

When to take it

Omeprazole is usually taken once daily, first thing in the morning. As it doesn’t affect your stomach, you can choose to take it with or without food.

How long do I take it for?

The duration of treatment depends on the condition being treated. Omeprazole is often taken short-term, generally for 4 to 8 weeks, for acid reflux and certain types of ulcers. However, for chronic conditions, patients may need to take it for longer.

What should I do if I miss a dose?

Forgetting a dose isn’t a cause for concern. Simply take the missed dose as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Never take a double dose to make up for a missed dose.

How long does Omeprazole take to work?

For acid reflux, most people will begin to feel better after 2 to 3 days of treatment; however, it can take up to four weeks to see the full effects of this medicine. Some patients may still experience some acid reflux symptoms during this time.

What lifestyle changes should I make while taking Omeprazole?

Making lifestyle changes while taking Omeprazole can help to improve its effectiveness as well as minimise symptoms of acid reflux. Consider doing the following:

Avoid certain foods

Research suggests that some foods can trigger acid reflux and should be avoided.

  • Avoid citrus fruits
  • Eat less spicy food
  • Limit chocolate
  • Watch your caffeine intake

Control your portions

Eat smaller meals more frequently, as large quantities of food eaten at once can trigger acid reflux, indigestion or heartburn.

  • Eat 5-6 smaller meals
  • Use smaller plates and bowls
  • Chew slowly
  • SBe careful not to overeat

Don’t eat before bed

Avoid eating within 3 hours of going to bed, as lying down can increase the risk of acid reflux.

  • Set a cut off time
  • Avoid late night snacking
  • Stay upright after eating

Maintain a healthy BMI

Research suggests that being overweight or obese can put pressure on the stomach, possibly causing acid to travel up the oesophagus.

  • Exercise regularly
  • Eat a balanced diet

Quit smoking

Smoking can increase stomach acid production, meaning those with GORD can benefit from quitting.

  • Consider a nicotine replacement
  • Track your progress with a stop smoking app

What are Omeprazole’s side effects?

Like all medicines, Omeprazole may cause side effects, although not everyone experiences them.

Common side effects

The most common side effects experienced by 1-10% of patients include:
  • A headache
  • Abdominal pain
  • Constipation or diarrhoea
  • Gas
  • Nausea or vomiting

Uncommon side effects

Some uncommon side effects which may affect up to 1 in 100 people include:
  • Swollen feet or ankles
  • Trouble sleeping (insomnia)
  • Dizziness
  • A tingling sensation
  • Vertigo (a feeling that you or your surroundings are moving )
  • Changes in blood tests that check how the liver is working
  • A skin rash, hives or itchy skin

Rare side effects

Some rare side effects that may affect up to 1 in 1,000 people include:
  • A lower number of white blood cells or platelets
  • Low sodium levels
  • Feeling agitated, confused or depressed
  • Changes in taste
  • Eyesight troubles such as blurry vision
  • Wheezing or shortness of breath
  • Skin rash when exposed to sunlight
  • Joint pains or muscle pains

If you develop more serious side effects, such as an allergic reaction, stop taking these capsules and contact your doctor immediately. Symptoms of an allergic reaction may include:

  • Sudden wheezing
  • Swelling of the lips, tongue and throat
  • Trouble swallowing

A complete list of side effects can be found in the patient information leaflet.

Does Omeprazole interact with any other medicines?

Omeprazole has the potential to interact with several medicines. It is important that you tell your doctor if you are taking any of the following medicines:

  • Ketoconazole, itraconazole, posaconazole or voriconazole (used to treat fungal infections)
  • Digoxin (for heart problems)
  • Diazepam (for treating anxiety, or epilepsy)
  • Phenytoin (for epilepsy)
  • Warfarin or other vitamin K blockers (used to thin the blood)
  • Rifampicin (for tuberculosis)
  • Atazanavir, Saquinavir and Nelfinavir (used to treat HIV infections)
  • Tacrolimus (for organ transplants)
  • St John’s wort (used to treat mild depression)
  • Cilostazol (for intermittent claudication)
  • Clopidogrel (used to prevent blood clots (thrombi))
  • Erlotinib (used to treat cancer)
  • Methotrexate (for inflammatory conditions)

For a full list of potential interactions, please visit the Pantoprazole interactions checker on the BNF website.

What safety advice should be followed when taking Omeprazole?

For more information, refer to the safety information table below:

Category Status Advice
Alcohol Avoid Although alcohol doesn’t affect the way Omeprazole works, it can increase stomach acid production and worsen symptoms. It's best to avoid alcohol if possible.
Pregnancy Consult your doctor Omeprazole may be used during pregnancy if its benefits outweigh the potential risks. If you are pregnant, consult your doctor to evaluate whether this medication is safe for you.
Breastfeeding Consult your doctor Omeprazole can pass into breastmilk. However, at regular doses, it is unlikely to affect your baby. It is best to consult your doctor to see if breastfeeding is safe for you and your baby.
Driving Safe Omeprazole is unlikely to affect your ability to drive or use machines.

How should this medicine be stored and disposed of?

How to store

Make sure to keep this medicine in its original packaging and do not store it above 25°C. Keep it protected from excessive light and moisture.

Disposal

Take any unused or expired medicines to your nearest pharmacy to ensure they are disposed of safely. Do not throw away any medicines in your household waste or flush them down the toilet.

Can I buy Omeprazole over the counter?

Yes, you can buy Omeprazole 20 mg tablets over the counter without a prescription. However, the 10 mg, 20 mg and 40 mg capsules require a prescription from a doctor. Our doctors will issue a prescription if they believe Omeprazole is suitable for you. They will check for drug interactions, and your other medical conditions.

How can I buy Omeprazole online from euroClinix?

You can buy Omeprazole 10 mg and 20 mg capsules online from euroClinix.

Follow these simple steps:

  1. Complete a quick online consultation to check your eligibility.
  2. UK-registered doctors review your responses to ensure the medication is right for you.
  3. Upon approval, an e-prescription will be issued.
  4. Enjoy free delivery from our licensed pharmacy with tracking details.

Your privacy is our top priority. euroClinix uses secure, encrypted transactions and complies with UK’s medical standards to keep your information confidential.

Start your online consultation today to enjoy professional care from the comfort of your home.

Why should I choose euroClinix?

euroClinix is trusted by thousands of users in the UK for its safe and convenient service. Here’s why:

  • Experienced doctors manage your consultations and prescriptions.
  • Online consultations, quick approvals, and discreet doorstep delivery add to the convenience.
  • A supportive team is on hand to answer treatment-related questions or concerns.
  • Patients can manage their prescriptions hassle-free through our secure platform.

Join thousands who trust euroClinix for their healthcare needs and take control of your health today.

How much is Omeprazole?

The price of Omeprazole at euroClinix includes everything you need:

  • Free online consultation with our experienced doctors
  • Free prescription, if approved
  • Free delivery straight to your door

Our pricing is transparent, with no hidden fees. Order today and benefit from our complete, all-inclusive service.

What alternatives are available?

If this medicine is not right for you, we have other options. These include Nexium, Rabeprazole, Pantoprazole, and Lansoprazole. These are also PPIs and work in a similar way to Omeprazole.

Medicine name Active ingredient Form Onset of action Availability Price from
Omeprazole Omeprazole Capsules, tablets, oral liquid, powder for solution 1-2 hours OTC and prescription (depending on strengths) -
Nexium Esomeprazole Capsules, tablets, solution for injection 1.5 hours Prescription only -
Rabeprazole Rabeprazole Tablets 1 hours Prescription only -
Pantoprazole Pantoprazole Tablets and solution for injection ~2 hours Prescription only -
Lansoprazole Lansoprazole Capsules and tablets 1.5 hours Prescription only -

Omeprazole FAQs

Are there any long-term side effects?
What is the difference between Lansoprazole and Omeprazole?
Can you take Gaviscon with Omeprazole?
Can Omeprazole cause constipation​?
What should I do if Omeprazole isn’t working for me?
Are there any discounts for being a new user?
Is it safe to order online?
Will my order be confidential?
What are the delivery options available?

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Medically reviewed by Dr. Caroline Fontana Written by our editorial team Last reviewed 06-12-2024
Omeprazole information
Type of medicine Proton pump inhibitor*
Used for Relieving the symptoms of acid reflux
Active ingredient(s) Omeprazole
Works by Binding to proton pumps and blocking them to reduce the overall stomach acidity.
Effective within 2 days to 4 weeks
Suitable for Adults aged 18 or older
Available as Gastro-resistant capsules
Available strength 10 mg and 20 mg capsules
Usage Take one capsule once daily
Manufacturer Various
Branded available No
Storage Store in the original packaging below 25°C
Prescription required? Yes, get it FREE with our online consultation
Who is suitable for an online consultation** Adults with acid reflux symptoms

*Proton pump inhibitors (PPIs) are medications that reduce the amount of acid produced in the stomach

**Note: Our medical team must review your online consultation before approving this treatment. They will determine if the requested treatment and quantity are safe, appropriate, and effective for you.

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